Modern web apps without JavaScript bundling or transpiling
The first crucial change is that ES6 is now supported by all browsers that matter. Chrome, Edge, Safari, and Firefox fully support ES6. The last major hold out was IE11, but Microsoft mercifully announced its end of life this year.
This means we don't need a transpiling step to turn ES6 into something that'll run in the browser. It runs just fine, no changes needed. That's huge.
The second crucial change is that HTTP2 is now the norm. With HTTP2, you no longer pay a large penalty for sending many small files instead of one big file. A single connection can multiplex all the responses you need. No more managing multiple connections, paying for multiple SSL handshakes. This means that bundling all your JavaScript into a single file loses many of its performance benefits (yes, yes, tree-shaking is still one).
A pleasant trip down javascript memory lane.